Dermatologist Reviews: DRMTLGY Peptide Night Cream

A patient recently asked me if the DRMTLGY Peptide Night Cream Face Moisturizer was worth trying. As a dermatologist, I had never heard of this particular product, so I decided to check it out! Moisturizers that contain peptides are becoming increasingly popular, but are they really worth $42? Let’s break down the ingredients and evaluate how well they deliver on their promises.

Overview of Peptides in the Product

The key active ingredients in this night cream include several peptides: Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, and Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine. Peptides are small chains of amino acids that act as signaling molecules in the skin, triggering cells to produce more collagen and elastin. They’re primarily known for their anti-aging benefits, with claims that they can reduce fine lines and wrinkles by boosting collagen production.

Click the video to the right for a whirlwind overview of peptides, or read on for more info!

In the case of Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7, these peptides work in synergy as part of the Matrixyl 3000 complex, which is designed to reduce inflammation and encourage collagen synthesis. However, most of the research supporting peptides like these comes from in vitro studies (i.e., studies in a lab setting, not on human skin). While these ingredients are promising, the evidence for their effectiveness on real skin is still developing.

Grade: C+

While peptides can be beneficial for anti-aging, they’re not miracle workers, and there are cheaper alternatives on the market with similar ingredients. The peptides in this product are solid but don’t stand out compared to competitors.

Hydrating Ingredients: Humectants, Emollients, and Occlusives

The DRMTLGY Peptide Night Cream includes a combination of humectants, emollients, and occlusives, each playing a critical role in skin hydration and barrier support.

Humectants (Glycerin, Hyaluronic Acid): These ingredients draw moisture from the environment into the skin, keeping it hydrated and plump. They ensure that water stays in the upper layers of the skin, preventing dehydration.

Emollients (Squalane, Ceramides):

These smooth and soften the skin by filling in the gaps between skin cells. Squalane mimics natural oils, while ceramides strengthen the skin’s barrier, keeping it healthy and resilient.

Occlusive (Shea Butter): This rich ingredient acts as a protective layer on the skin, sealing in moisture and preventing water loss. It’s particularly beneficial for dry or compromised skin, offering a soothing and reparative effect.

The balance of these three types of moisturizing agents makes the product effective in maintaining skin hydration and protecting the skin barrier, earning the hydrating ingredients an A-grade.

Grade: A

The combination of these hydrating ingredients makes this product a standout when it comes to restoring and maintaining the skin barrier. It’s especially beneficial for dry or sensitive skin types.

Usage

For best results, apply a small amount of DRMTLGY Peptide Night Cream to clean, dry skin as the last step in your nighttime skincare routine. Use it after applying any serums or active ingredients like retinol. If you’re new to this product, start by using it every other night to ensure your skin tolerates it, then gradually increase to nightly use.

Time to See Results

The immediate benefits of this product, like hydration and improved skin texture, can be seen within the first week of use. However, for more significant results, such as reduced fine lines or increased skin firmness, it usually takes about 8-12 weeks of consistent use. Peptides take time to work, and they require patience.

Side Effects

This product is formulated without alcohol, fragrances, or essential oils, making it suitable for sensitive skin. However, some users with acne-prone skin might want to patch-test first, as some ingredients (like Isopropyl Palmitate) may clog pores for those prone to breakouts.

Texture and Feel

The texture of the DRMTLGY Peptide Night Cream is lightweight yet creamy. It absorbs quickly without leaving a greasy residue, making it a great option for both dry and combination skin. After application, the skin feels soft, hydrated, and smooth.

Packaging

The product comes in a jar, which is a common packaging for moisturizers but not always the most hygienic. Every time you open the jar, air and bacteria can potentially degrade the effectiveness of the ingredients, particularly the peptides. A pump dispenser would have been a better choice to protect the formula.

Price and Value

Priced at around $42, this moisturizer is mid-range for a peptide-based night cream. It’s available on DRMTLGY’s website and other online retailers. While the hydrating ingredients are top-notch, the peptides don’t justify the price. You can find similar moisturizers at a lower cost that provide equally effective hydration and barrier repair.

Comparisons

When comparing DRMTLGY Peptide Night Cream to its competitors, such as The Ordinary Buffet or Neutrogena Hydro Boost, it performs well in terms of hydration but falls short on the peptide front. The Ordinary Buffet offers a more peptide-rich formula at a fraction of the cost, while Neutrogena Hydro Boost focuses purely on hydration with hyaluronic acid, also at a lower price point.

Pros:

Excellent hydrating and barrier-supporting ingredients.

Lightweight, non-greasy texture.

Free from alcohol, fragrance, and essential oils.

Cons:

Peptides may not be as effective as advertised.

Jar packaging could compromise ingredient stability.

Higher price compared to other similar products.

Dermatologist’s Opinion

Overall Grade: B-

While the DRMTLGY Peptide Night Cream excels in providing hydration and barrier repair, the peptides fall short of the anti-aging claims. For those mainly seeking moisture and skin barrier support, this is an okay option. It’s too expensive for what it is. However, if you’re specifically looking for potent peptide benefits, there are better, more affordable choices on the market.

Is DRMTLGY Peptide Night Cream safe for sensitive skin?

Yes, it’s free from common irritants like fragrance, alcohol, and essential oils, making it suitable for sensitive skin. However, always patch test new products.

How often should I use it?

It can be used nightly as part of your evening skincare routine. Start slow if combining it with other active ingredients like retinoids.

Can I use this with retinol?

Yes, apply your retinol first, allow it to absorb, then follow with the Peptide Night Cream to lock in moisture.

Is it suitable for acne-prone skin?

While generally non-comedogenic, some ingredients (like Isopropyl Palmitate) could potentially clog pores, so patch testing is recommended.

How long will it take to see results?

You’ll notice improved hydration within days, but for anti-aging benefits, expect to wait at least 8-12 weeks.